"I profoundly regret the decision this house has taken," May told lawmakers in a short speech right after the voting.

She added that the choices facing Britain were "unenviable", but because of the rejection of her deal. "They are choices that must be faced," she said.

May has secured legally binding changes to the deal on Monday night, but rebel lawmakers of her Conservative Party and those from the opposition Labour Party had said that these changes were not enough to persuade MPs to back the agreement reached by London and Brussels in November 2018 after years of painful negotiations.

"The reality is that nothing has changed," Jeremy Corbyn, the leader of Labour Party, said in the parliament. "Nothing has changed. Not one single word was changed."

Corbyn said the Labour party put forward the idea of "remain and reform" in the referendum campaign.

With her Brexit deal rejected again in the parliament, the prime minister then faces a possible defeat on a second vote on Wednesday to prevent a no-deal Brexit on March 29, and a third vote on Thursday to extend the Article 50 divorce process, likely until the end of June. 

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